The Protein Microsequencing Facility provides different analytical services aimed at structurally characterizing peptides and proteins. The Facility is equipped with analytical HPLC systems, 2D gel electrophoresis apparatus and mass spectrometers. Access to mass spectrometry is a crucial key in the emerging field of proteomics, which is giving a major contribution to the description and understanding of biological processes at the molecular level. Our principal approach for the analysis of proteins is 'bottom-up' proteomics, where all proteins are proteolytically digested, producing signature peptides of the original proteins. The Facility is intended to be a resource for both local and extramural scientific community.