Fulvio Mavilio
Pubblicazioni Selezionate
Simeone A., Acampora D., Arcioni L., Andrews P.W., Boncinelli E., Mavilio F. (1990). Sequential activation of human HOX2 homeobox genes by retinoic acid in embryonal carcinoma cells. Nature 346: 763-766.
Ferrari G., Rossini S., Giavazzi R., Maggioni D., Nobili N., Soldati M., Ungers G., Mavilio F., Gilboa E., Bordignon C. (1991). An in vivo model of somatic cell gene therapy for human severe combined immunodeficiency. Science 251: 1363-1366.
Bordignon C., Notarangelo L.D., Nobili N., Ferrari G., Casorati G., Panina P., Mazzolari E., Maggioni D., Rossi C., Servida P., Ugazio A.G., Mavilio F. (1995). Gene therapy in peripheral blood lymphocytes and bone marrow for ADA- immunodeficient patients. Science 270: 470-475.
Bonini C., Ferrari G., Verzeletti S., Servida P., Zappone E., Ruggieri L. Ponzoni M., Rossini S., Mavilio F., Traversari C., Bordignon C. (1997). HSV-TK gene transfer into donor lymphocytes for control of allogeneic Graft-Versus-Leukemia. Science 276: 1719-1724
Ferrari G., Cusella-De Angelis G., Coletta M., Paolucci E., Stornaiuolo A., Cossu G., Mavilio F. (1998). Muscle regeneration by bone marrow-derived myogenic progenitors. Science 279: 1528-1530.
Berthelsen J., Zappavigna V., Mavilio F., Blasi F. (1998). Prep1, a novel functional partner of Pbx proteins. EMBO J. 17:1423-1433
Grande A., Piovani B., Aiuti A., Ottolenghi S., Mavilio F., Ferrari G. (1999). Transcriptional targeting of retroviral vectors to the erythroblastic progeny of transduced hematopoietic stem cells. Blood 93: 3276-3285
Berthelsen J., Kilstrup-Nielsen C., Blasi F., Mavilio F., Zappavigna V. (1999). The subcellular localization of PBX1 and EXD proteins depends on nuclear import and export signals, and is modulated by association with PREP1 and HTH. Genes Dev. 13: 946-953
Ferrari G., Stornaiuolo A., Mavilio F. (2001). Bone marrow transplantation. Failure to correct muscular dystrophy. Nature 411: 1014-1015
Bonini C., Grez M., Traversari C., Ciceri F., Marktel S., Ferrari G., Dinauer M., Sadat M., Aiuti A., Deola S., Radrizzani M., Hagenbeek A., Apperley J., Ebeling S., Martens A., Kolb H.J., Weber M., Lotti F., Grande A., Weissinger E., Bueren J.A., Lamana M., Falkenburg J.H.F., Heemskerk M.H.M., Austin T., Kornblau S., Marini F., Benati C., Magnani Z., Cazzaniga S., Toma S., Gallo-Stampino C., Introna M., Slavin S., Greenberg P.D., Bregni M., Mavilio F., Bordignon C. (2003). Safety of retroviral gene marking with a truncated NGF receptor. Nature Med. 9:367-369
Cavazzana-Calvo M., Thrasher A., Mavilio F. (2004). The future of gene therapy. Balancing the risks and benefits of clinical trials. Nature 427: 779-781
Recchia A, Bonini C., Magnani Z., Urbinati F., Sartori D., Muraro S., Tagliafico E., Bondanza A., Lupo Stanghellini M.T., Bernardi M., Pescarollo A., Ciceri F., Bordignon C., Mavilio F. (2006). Retroviral vector integration deregulates gene expression but has no consequence on the biology and function of transplanted T cells. Proc. Natl. Acad Sci. USA 103:1457-1462
Mavilio F., Pellegrini G., Ferrari S., Di Nunzio F., Di Iorio E., Recchia A., Maruggi G., Ferrari G., Provasi E., Bonini C., Capurro S., Conti A., Magnoni C., Giannetti A., De Luca, M. (2006). Correction of junctional epidermolysis bullosa by transplantation of genetically modified epidermal stem cells. Nature Med. 12:1397-1402
Aiuti A., Cassani B., Andolfi G., Mirolo M., Biasco L., Recchia A., Urbinati F., Valacca C., Scaramuzza S., Cazzola M., Sartori D., Ambrosi A., Di Serio C., Roncarolo M.G., Mavilio F., and Bordignon C. (2007). Multilineage hematopoietic reconstitution without clonal selection in ADA-SCID patients treated with stem cell gene therapy. J. Clin. Invest. 17:2233-2240
Barbaro V., Testa A., Di Iorio E., Mavilio F., Pellegrini G., De Luca M. (2007). C/EBP? regulates cell cycle and self-renewal of human limbal stem cells. J. Cell Biol. 177:1037-1049
Cattoglio C., Facchini G., Sartori D., Antonelli A., Miccio A., Cassani B., Schmidt M., von Kalle C., Howe S., Thrasher A.J., Aiuti A., Ferrari G., Recchia A., Mavilio F. (2007). Hot spots of retroviral integrations in human CD34+ hematopoietic cells. Blood 110:1770-1778
Mavilio F., Ferrari G. (2008). Genetic modification of somatic stem cells. The progress, problems and prospects of a new therapeutic technology. EMBO Reports, 9:S64-S69
Felice B., Cattoglio C., Cittaro D., Testa A., Miccio A., Ferrari G., Luzi L., Recchia A., Mavilio F. (2009) Transcription factor binding sites are genetic determinants of retroviral integration in the human genome. PLoS One 4:e4571
Gabriel R., Eckenberg R., Paruzynski A., Bartholomae C.C., Nowrouzi A., Arens A., Howe S.J., Recchia A., Cattoglio C., Wang W., Faber K., Schwarzwaelder K., Kirsten R., Deichmann A., Ball C.R., Balaggan K.S., Yáñez-Muñoz R.J., Ali R.A., Gaspar H.B., Biasco L., Aiuti A., Cesana D., Montini E., Naldini L., Cohen-Haguenauer O., Mavilio F., Adrian J. Thrasher A.J., Glimm H., von Kalle C., Saurin W., Schmidt M. (2009). Comprehensive genomic access to vector integration in clinical gene therapy. Nature Med. (in press)
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