The research in the lab aims at establishing the structure-function relationship of disease-relevant biological macromolecules. Our approach is to obtain high resolution structures of proteins using x-ray crystallography, and to analyze them in order to fully understand how the structure of a protein leads to its function, and how their regulation occurs at the atomic level. Applications of our research are relevant to cancer, autoimmune and genetic diseases, as well as for the design of specific drugs against foreign pathogens.